Drugs & Vitamins

Ranolazine extended-release tablets Active Ingredients: Ranolazine extended-release tablets Representative Names: Ranexa Available Product Images: What are Ranolazine extended-release tablets? What should I tell my health care provider before I take this medicine? How should this medicine be used? What if I miss a dose? What drug(s) may interact with Ranolazine? What side effects may I notice from receiving Ranolazine? What should I watch for while taking Ranolazine? Where can I keep my medicine? What are Ranolazine extended-release tablets? (Back to top) RANOLAZINE (Ranexa®) is a medicine used to treat chronic angina. Ranolazine relieves chest pain (angina) when taking regularly. Ranolazine does not relieve an acute episode of angina or chest pain. Ranolazine should only be taken by patients who have tried other medicines for angina, and still do not have adequate relief of symptoms. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •heart disease •heart rhythm problems (fast heartbeat, family history of QT prolongation, congenital long QT syndrome) •low blood levels of potassium or magnesium •kidney disease •liver disease •an unusual reaction to Ranolazine, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should this medicine be used? (Back to top) Take ranolazine tablets by mouth. Follow the directions on the prescription label. Swallow the tablets whole. Do not cut, break, crush, or chew the tablets. The tablets can be taken with or without food. Do not take your medication with grapefruit juice. Take your doses at regular intervals. Do not take your medicine more often then directed. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. What drug(s) may interact with Ranolazine? (Back to top) Do not take ranolazine with any of the following: •abarelix •aprepitant •certain antibiotics (chloramphenicol, clarithromycin, dalfopristin; quinupristin, erythromycin, telithromycin, troleandomycin) •certain chemotherapy drugs used to treat cancer (arsenic trioxide, imatinib, STI-571) •certain medicines for depression or mental problems (chlorpromazine, fluvoxamine, haloperidol, mesoridazine, thioridazine, pimozide, ziprasidone) •certain medicines to control heart rhythm (amiodarone, disopyramide, dofetilide, flecainide, procainamide, propafenone, quinidine, sotalol) •certain medicines to treat malaria (chloroquine, halofantrine, quinidine) •cisapride •conivaptan •cyclosporine •danazol •diltiazem •droperidol •fluvoxamine •grapefruit or grapefruit juice •isoniazid (INH) •medicines for fungal infections (fluconazole, itraconazole, ketoconazole, voriconazole) •medicines for HIV infection (amprenavir, atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir) •methadone •mifepristone, RU-486 •pentamidine •verapamil Ranolazine may also interact with the following medications: •alfuzosin •certain antibiotics (ciprofloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin) •digoxin •efavirenz •eplerenone •ergot alkaloids used for migraine (such as ergotamine, dihydroergotamine) •herbal or dietary supplements such as St. John's wort or red yeast rice •local anesthetics or general anesthetics •medicines for depression •medicines for erectile dysfunction •medicines for seizures (carbamazepine, phenobarbital, phenytoin, primidone) •medicines for high cholesterol (atorvastatin, lovastatin, simvastatin) •nicardipine •some medicines for malaria (mefloquine, quinine) •some medicines for mental problems (fluphenazine, perphenazine, risperidone, trifluoperazine) •some medicines for pain (codeine, hydrocodone, oxycodone, propoxyphene) •some medicines for stomach problems (octreotide, palonosetron, prochlorperazine) •rifampin, rifapentine, or rifabutin •sirolimus •tacrolimus •zafirlukast Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from receiving Ranolazine? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •blurred vision •difficulty breathing or shortness of breath •fainting spells •fast, irregular or pounding heartbeat (palpitations) •low or high blood pressure •numbness or tingling feelings •persistent nausea or vomiting •ringing in the ears •tremor or shakiness •slow heartbeat (fewer than 50 beats per minute) •swelling of the legs or feet Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •constipation •drowsiness •dry mouth •headache •mild dizziness •mild nausea or vomiting •stomach upset What should I watch for while taking Ranolazine? (Back to top) Ranolazine does not relieve an acute attack of angina or chest pain. Symptoms of an angina attack might include chest pain, reduced tolerance of exercise or walking, and/or shortness of breath. Contact your doctor if you feel palpitations or if you have fainting spells. Ranolazine may produce changes in the electrocardiogram (ECG). Your health care provider may check your heart rhythm by ordering an ECG while taking ranolazine. You may feel dizzy or lightheaded while taking ranolazine. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks; they can make you dizzy or increase flushing and rapid heartbeats. If you are going to have surgery, tell your prescriber or health care professional that you are taking ranolazine. Where can I keep my medicine? (Back to top) Keep out of the reach of children. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date. Last Updated:08/14/2006 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.